TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat.

ABSTRACT:

Background

Accurate and sensitive imaging biomarkers are required to study the progression of white matter (WM) inflammation in neurodegenerative diseases. Radioligands targeting the translocator protein (TSPO) are considered sensitive indicators of neuroinflammation, but it is not clear how well the expression of TSPO coincides with major histocompatibility complex class II (MHCII) molecules in WM. This study aimed to test the ability of TSPO to detect activated WM microglia that are immunohistochemically positive for MHCII in rat models of prodromal Alzheimer's disease and acute subcortical stroke.

Methods

Fischer 344 wild-type (n = 12) and TgAPP21 (n = 11) rats were imaged with [¹⁸F]FEPPA PET and MRI to investigate TSPO tracer uptake in the corpus callosum, a W

SUBMITTER: Al-Khishman NU 

PROVIDER: S-EPMC7524910 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature