Guanosine modulates SUMO2/3-ylation in neurons and astrocytes via adenosine receptors.

ABSTRACT: SUMOylation is a post-translational modification (PTM) whereby members of the Small Ubiquitin-like MOdifier (SUMO) family of proteins are conjugated to lysine residues in target proteins. SUMOylation has been implicated in a wide range of physiological and pathological processes, and much attention has been given to its role in neurodegenerative conditions. Due to its reported role in neuroprotection, pharmacological modulation of SUMOylation represents an attractive potential therapeutic strategy in a number of different brain disorders. However, very few compounds that target the SUMOylation pathway have been identified. Guanosine is an endogenous nucleoside with important neuromodulatory and neuroprotective effects. Experimental evidence has shown that guanosine can modulate different i

SUBMITTER: Zanella CA 

PROVIDER: S-EPMC7524998 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature