Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific.

ABSTRACT:

Introduction

Despite a wealth of epidemiological evidence that cumulative parental lifetime stress experiences prior to conception are determinant of offspring developmental trajectories, there is a lack of insight on how these previous stress experiences are stored and communicated intergenerationally. Preconception experiences may impact offspring development through alterations in transcriptional regulation of the placenta, a major determinant of offspring growth and sex-specific developmental outcomes. We evaluated the lasting influence of maternal and paternal preconception stress (PCS) on the mid-gestation placenta and fetal brain, utilizing their transcriptomes as proximate readouts of intergenerational impact.

Methods

To assess the combined vs. dominant influence of

SUBMITTER: Cisse YM 

PROVIDER: S-EPMC7525040 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature