Serum Bicarbonate as a Surrogate for pH in Hemodialysis: A Pilot Study.

ABSTRACT:

Rationale & objective

Excess morbidity and mortality are associated with both high and low serum bicarbonate levels in epidemiologic studies of patients with end-stage kidney disease (ESKD) receiving hemodialysis. The Kidney Disease Outcomes Quality Initiative (KDOQI) recommends modifying dialysate bicarbonate concentration to achieve a predialysis serum bicarbonate level ≥ 22 mmol/L, measured as total carbon dioxide (CO₂). This practice assumes that total CO₂ is an adequate surrogate for acid-base status, yet its surrogacy performance is unknown in ESKD. We determined acid-base status at the beginning and end of hemodialysis using total CO₂ and pH and tested whether total CO₂ is an appropriate surrogate for acid-base status.

Study des

SUBMITTER: Woodell TB 

PROVIDER: S-EPMC7525140 | biostudies-literature | 2020 Jan-Feb

REPOSITORIES: biostudies-literature