Early mechanical ventilation in patients with Guillain-Barre syndrome at high risk of respiratory failure: a randomized trial.

ABSTRACT:

Introduction

About 30% of patients with Guillain-Barré syndrome become ventilator dependent, of whom roughly 75% develop pneumonia. This trial aimed at assessing the impact of early mechanical ventilation (EMV) on pneumonia occurrence in GBS patients. We hypothesize that EMV will reduce the incidence of pneumonia.

Methods

This was a single centre, open-label, randomized controlled trial performed on two parallel groups. 50 intensive care unit adults admitted for Guillain-Barré syndrome and at risk for acute respiratory failure. Patients were randomized to early mechanical ventilation via face-mask or endotracheal intubation owing to the presence or absence of impaired swallowing (experimental arm), or to conventional care (control arm). The primary outcome was the incidence

SUBMITTER: Melone MA 

PROVIDER: S-EPMC7525233 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature