Dataset Information

Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study.

ABSTRACT:

Introduction

To compare the safety and efficacy of the Therapeutic Hyper-CL™ lens versus a standard bandage contact lens (PureVision B&L) for chronic corneal edema.

Methods

Prospective, multicenter, randomized, crossover study. Chronic corneal edema patients were randomized to one of two arms. The first arm was fitted with the Therapeutic Hyper-CL™ lens while the second arm was fitted with a standard soft bandage contact lens. Both arms were treated with 5% sodium chloride 6 times a day. After a 7-day treatment period, there was a 7-day washout period, after which the arms were crossed over. Patients were evaluated at days 0 (baseline), 7 (following first treatment allocation), 14 (following washout), and 21 (following second treatment allocation). The primary outcomes were 3 lines of BCVA (best corrected visual acuity) improvement.

Results

In total, 49 patients were enrolled. There was significantly greater BCVA improvement rate >3 lines (30.4% versus 17.4%, P=0.04) in the Therapeutic Hyper-CL™ lens group. The mean change in BCVA lines was significantly greater for the Therapeutic Hyper-CL™ lens (3.4 ± 6.7 versus 0.9 ± 2.3, P=0.02).

Conclusions

The Therapeutic Hyper-CL™ lens was associated with a higher chance for significant visual acuity improvement when compared to a standard bandage contact lens combined with 5% sodium chloride. This trial is registered with NCT02660151.

SUBMITTER: Daphna O

PROVIDER: S-EPMC7525312 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study.

Daphna Ofer O Mimouni Michael M Keshet Yariv Y Ben Ishai Meydan M Barequet Irina S IS Knyazer Boris B Mrukwa-Kominek Ewa E Zarnowski Tomasz T Chen-Zion Malca M Marcovich Arie A

Journal of ophthalmology 20200921

<h4>Introduction</h4>To compare the safety and efficacy of the Therapeutic Hyper-CL™ lens versus a standard bandage contact lens (PureVision B&L) for chronic corneal edema.<h4>Methods</h4>Prospective, multicenter, randomized, crossover study. Chronic corneal edema patients were randomized to one of two arms. The first arm was fitted with the Therapeutic Hyper-CL™ lens while the second arm was fitted with a standard soft bandage contact lens. Both arms were treated with 5% sodium chloride 6 times ...[more]

PMID: 33014443

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Project description:Contact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an approximate annualized incidence ranging from ~2 to ~20 cases per 10,000 wearers, and sometimes resulting in permanent vision loss. Research suggests that the pathogenesis of contact lens-associated microbial keratitis is complex and multifactorial, likely requiring multiple conspiring factors that compromise the intrinsic resistance of a healthy cornea to infection. Here, we outline our perspective of the mechanisms by which contact lens wear sometimes renders the cornea susceptible to infection, focusing primarily on our own research efforts during the past three decades. This has included studies of host factors underlying the constitutive barrier function of the healthy cornea, its response to bacterial challenge when intrinsic resistance is not compromised, pathogen virulence mechanisms, and the effects of contact lens wear that alter the outcome of host-microbe interactions. For almost all of this work, we have utilized the bacterium Pseudomonas aeruginosa because it is the leading cause of lens-related microbial keratitis. While not yet common among corneal isolates, clinical isolates of P. aeruginosa have emerged that are resistant to virtually all currently available antibiotics, leading the United States CDC (Centers for Disease Control) to add P. aeruginosa to its list of most serious threats. Compounding this concern, the development of advanced contact lenses for biosensing and augmented reality, together with the escalating incidence of myopia, could portent an epidemic of vision-threatening corneal infections in the future. Thankfully, technological advances in genomics, proteomics, metabolomics and imaging combined with emerging models of contact lens-associated P. aeruginosa infection hold promise for solving the problem - and possibly life-threatening infections impacting other tissues.

Project description:BackgroundTo evaluate the impact of the corneal contact lens virtual simulation teaching system on students' course experience and self-directed learning in 'corneal contact lens' education.MethodsThis study developed a virtual simulation experimental teaching system for 'corneal contact lens' education. A longitudinal comparison of the course experience and self-directed learning abilities of the same group of students at a university in Fujian Province before and after using the system was conducted through questionnaires. Pearson correlation analysis was used to determine the correlation between factors of course experience and self-directed learning abilities before and after the application of the virtual simulation experimental teaching system.ResultsA total of 290 valid questionnaires were collected from 145 optometry undergraduates (71 males, 74 females, average age 21.05 ± 0.82 years). Students completed questionnaires before and after using the virtual simulation teaching system. The evaluation of teaching improved from 4.05 to 4.45, basic skills mastery increased from 3.49 to 4.40, and overall course experience rose from 3.07 to 4.17. The system significantly enhanced self-directed learning abilities (P ≤ 0.05), with increased scores in teacher role expectations (3.91 to 4.41), independence (3.03 to 4.34), learning confidence (3.02 to 4.35), learning process evaluation (2.89 to 4.33), and learning strategy use (3.37 to 4.36). However, correlation analysis revealed a significant decrease in the correlation between students' confidence in learning ability, process evaluation, and strategy use after utilizing the virtual simulation technology.ConclusionVirtual simulation technology not only significantly enhanced students' experience in corneal contact lens courses but also improved their self-directed learning abilities. It changed students' cognition and behavior patterns regarding the learning process to some extent, providing new pathways and possibilities for the innovation and development of digital education in ophthalmology.

Dataset Information

Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study.

Introduction

Methods

Results

Conclusions

Publications

Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study.

Similar Datasets

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