Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation.

ABSTRACT: Immune tolerance research is essential for kidney transplantation. Other than antibody and T cell-mediated immune rejection, macrophage-mediated innate immunity plays an important role in the onset phase of transplantation rejection. However, due to the complexity of the kidney environment as well as its diversity and low abundance, studies pertaining to monocyte/macrophages in kidney transplantation require further elucidation. In this study, kidney samples taken from healthy human adults and biopsy specimens from patients undergoing rejection following kidney transplantation were analysed and studied. By conducting a single-cell RNA analysis, the type and status of monocyte/macrophages in kidney transplantation were described, in which monocyte/macrophages were observed to form two diffe

SUBMITTER: Wang J 

PROVIDER: S-EPMC7525314 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature