Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome.

ABSTRACT: Cascade genetic testing provides a method to appropriately focus colonoscopy use in families with Lynch syndrome (LS). However, research suggests that up to two-thirds at risk to inherit LS don't participate. Within the United States, no studies have assessed colonoscopy use within this elusive and high-risk subset. We set forth to (1) document colonoscopy use within those not undergoing genetic testing (NGT) and (2) identify factors associated with completing colonoscopy. Data came from a cross sectional survey of families with molecularly confirmed LS. One hundred seventy-six (176) adults participated; 47 of unknown variant status and 129 with variant status known (59 carriers/70 non-carriers). Despite a high level of awareness of LS (85%) and identical recommendations for colonoscopy, N

SUBMITTER: Hadley DW 

PROVIDER: S-EPMC7525436 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature