Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety.

ABSTRACT: Independent studies have observed that a paternal history of stress or trauma is associated with his children having a greater likelihood of developing psychopathologies such as anxiety disorders. This father-to-child effect is reproduced in several mouse models of stress, which have been crucial in developing a greater understanding of intergenerational epigenetic inheritance. We previously reported that treatment of C57Bl/6J male breeders with low-dose corticosterone (CORT) for 28 days prior to mating yielded increased anxiety-related behaviours in their male F1 offspring. The present study aimed to determine whether subchronic 7-day CORT treatment of male mice just prior to mating would be sufficient to induce intergenerational modifications of anxiety-related behaviours in offspring. W

SUBMITTER: Fennell KA 

PROVIDER: S-EPMC7525454 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature