HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation.

ABSTRACT: At the end of abscission, the residual midbody forms the so-called midbody remnant (MBR), a platform affecting cell fate with emerging key role in differentiation, development, and tumorigenicity. Depending on cell type and pathophysiological context, MBRs undergo different outcomes: they can be retained, released, internalized by nearby cells, or removed through autophagy-mediated degradation. Although mechanisms underlying MBR formation, positioning, and processing have been recently identified, their regulation is still largely unknown. Here, we report that the multifunctional kinase HIPK2 regulates MBR processing contributing to MBR removal. In the process of studying the role of HIPK2 in abscission, we observed that, in addition to cytokinesis failure, HIPK2 depletion leads to signifi

SUBMITTER: Sardina F 

PROVIDER: S-EPMC7525647 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature