Preclinical dosimetry models and the prediction of clinical doses of novel positron emission tomography radiotracers.

ABSTRACT: Dosimetry models using preclinical positron emission tomography (PET) data are commonly employed to predict the clinical radiological safety of novel radiotracers. However, unbiased clinical safety profiling remains difficult during the translational exercise from preclinical research to first-in-human studies for novel PET radiotracers. In this study, we assessed PET dosimetry data of six ¹⁸F-labelled radiotracers using preclinical dosimetry models, different reconstruction methods and quantified the biases of these predictions relative to measured clinical doses to ease translation of new PET radiotracers to first-in-human studies. Whole-body PET images were taken from rats over 240 min after intravenous radiotracer bolus injection. Four existing and two novel PET radiotracers

SUBMITTER: Garrow AA 

PROVIDER: S-EPMC7525662 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature