Long-term preoperative glycemic control restored the perioperative neutrophilic phagocytosis activity in diabetic mice.

ABSTRACT:

Background

The risk of surgical site infection has been reported to be higher in patients with poorly controlled diabetes. Since chronic hyperglycemia impairs neutrophil functions, preoperative glycemic control may restore neutrophil function. However, long-term insulin therapy may lead to a delay in surgery, which may be a problem, especially in cancer surgery. It is therefore unfortunate that there have been few studies in which the optimal duration of perioperative glycemic control for diabetes with chronic hyperglycemia was investigated. Therefore, we investigated the effects of preoperative long-term insulin therapy and short-term insulin therapy on perioperative neutrophil functions in diabetic mice with chronic hyperglycemia.

Methods

Five-week-old male C57BL/6 J mice

SUBMITTER: Fujimoto D 

PROVIDER: S-EPMC7525964 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature