Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae.

ABSTRACT:

Background

The mammalian Major Histocompatibility Complex (MHC) is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode antigen-presenting molecules expressed on the cell surface. The MHC class II sub-region contains genes expressed in antigen presenting cells. The antigen binding site is encoded by the second exon of genes encoding antigen presenting molecules. The exon 2 sequences of these MHC genes have evolved under the selective pressure of pathogens. Interspecific differences can be observed in the class II sub-region. The family Equidae includes a variety of domesticated, and free-ranging species inhabiting a range of habitats exposed to different pathogens and represents a model for studying this important

SUBMITTER: Klumplerova M 

PROVIDER: S-EPMC7525986 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature