The expression profile of virus-recognizing toll-like receptors in natural killer cells of Cypriot multiple sclerosis patients.

ABSTRACT:

Objective

The exact aetiology of multiple sclerosis (MS) remains elusive, although several environmental and genetic risk factors have been implicated to varying degrees. Among the environmental risk factors, viral infections have been suggested as strong candidates contributing to MS pathology/progression. Viral recognition and control are largely tasked to the NK cells via TLR recognition and various cytotoxic and immunoregulatory functions. Additionally, the complex roles of different TLRs in MS pathology are highlighted in multiple, often contradictory, studies. The present work aims to analyse the TLR expression profile of NK cells isolated from MS patients. Highly purified CD56⁺CD3^- NK cells isolated from peripheral blood of MS patients (n = 19) and heal

SUBMITTER: Deeba E 

PROVIDER: S-EPMC7526110 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature