Sevoflurane modulates breast cancer cell survival via modulation of intracellular calcium homeostasis.

ABSTRACT:

Background

Some retrospective and in vitro studies suggest that general anesthetics influence breast cancer recurrence and metastasis. We compared the effects of general anesthetics sevoflurane versus propofol on breast cancer cell survival, proliferation and invasion in vitro. The investigation focused on effects in intracellular Ca²⁺ homeostasis as a mechanism for general anesthetic-mediated effects on breast cancer cell survival and metastasis.

Methods

Estrogen receptor-positive (MCF7) and estrogen receptor-negative (MDA-MB-436) human breast cancer cell lines along with normal breast tissue (MCF10A) were used. Cells were exposed to sevoflurane or propofol at clinically relevant and extreme doses and durations for dose- and time-dependence studies. Cell survival

SUBMITTER: Deng X 

PROVIDER: S-EPMC7526115 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature