Roles of IFN-γ in tumor progression and regression: a review.

ABSTRACT:

Background

Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer. Moreover, it IFN-γ may inhibit angiogenesis in tumor tissue, induce regulatory T-cell apoptosis, and/or stimulate the activity of M1 proinflammatory macrophages to overcome tumor progression. However, the current understanding of the roles of IFN-γ in the tumor microenvironment (TME) may be misleading in terms of its clinical application.

Main body

Some researchers believe it has anti-tumorigenic properties, while others suggest that it contributes to tumor growth and

SUBMITTER: Jorgovanovic D 

PROVIDER: S-EPMC7526126 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature