Hepatic stellate cells contribute to liver regeneration through galectins in hepatic stem cell niche.

ABSTRACT:

Background

As a critical cellular component in the hepatic stem cell niche, hepatic stellate cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver regeneration, and fibrogenesis. However, the signaling of HSCs, particularly that involved in promoting hepatic stem cell expansion, remains unclear. While the overexpression of galectins has been identified in regenerating liver tissues, their involvement in cell-cell interactions between HSCs and hepatic stem cells remains to be elucidated.

Methods

To generate a liver regeneration rat model and establish a hepatic oval cell microenvironment as a stem cell niche, 2-acetylaminofluorene treatment plus partial hepatectomy was performed. Immunofluorescence staining was conducted to detect the emerg

SUBMITTER: Ge JY 

PROVIDER: S-EPMC7526193 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature