Comprehensive analysis of angiogenesis-related genes and pathways in early diabetic retinopathy.

ABSTRACT:

Background

Angiogenesis is an important parameter in the development of diabetic retinopathy (DR), and it is indicative of an early stage evolving into a late phase. Therefore, examining the role of angiogenic factors in early DR is crucial to understanding the mechanism of neovascularization.

Methods

The present study identified hub genes and pathways associated with angiogenesis in early DR using bioinformatics analysis. Genes from published literature and Gene Expression Omnibus (GEO) were collected and analysed.

Results

We collected 73 genes from 70 published studies in PubMed, which were referred to as DR-related gene set 1 (DRgset1). The gene expression profile of GSE12610 was downloaded, and 578 differentially expressed genes (DEGs) between diabetic and normal

SUBMITTER: Gu C 

PROVIDER: S-EPMC7526206 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature