MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells.

ABSTRACT:

Background

Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these deaths. MicroRNAs are endogenous noncoding RNAs that have been integrated into almost all the physiological and pathological processes, including metastasis. In the present study, the role of miR-128 in breast cancer was investigated.

Results

Compared to the corresponding adjacent normal tissue, the expression of miR-128 was significantly suppressed in human breast cancer specimens. More importantly, its expression level was reversely correlated to histological grade of the cancer. Ectopic expression of miR-128 in the aggressive breast cancer cell line MDA-MB-231

SUBMITTER: Cao D 

PROVIDER: S-EPMC7526227 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature