Pharmacokinetic Study of Epinephrine Hydrofluoroalkane (Primatene MIST) Metered-Dose Inhaler.

ABSTRACT: Background: Primatene^® MIST CFC, an epinephrine metered-dose inhaler (MDI), was discontinued from the market owing to environmental concerns from its use of chlorofluorocarbon (CFC) propellant. As a result, a new epinephrine MDI was developed using hydrofluoroalkane (HFA) propellant. This article reports the pharmacokinetic (PK) profile of the newly Food and Drug Administration-approved epinephrine HFA MDI. Methods: A randomized, evaluator-blinded, active-controlled, single-dose, two-arm crossover study was conducted to evaluate the PK profile of epinephrine HFA (Primatene^® MIST) and epinephrine CFC (Primatene^® MIST CFC) in 23 healthy volunteers to characterize the epinephrine absorption extent and rate. The study was performed a

SUBMITTER: Kerwin EM 

PROVIDER: S-EPMC7526295 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature