Inhaled therapies for chronic obstructive pulmonary disease: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To integrate evidence from randomised controlled trials (RCTs) and observational studies on the efficacy of inhaled treatments for chronic obstructive pulmonary disease using network meta-analyses.

Methods

Systematic searches MEDLINE and Embase based on predetermined criteria. Network meta-analyses of RCTs investigated efficacy on exacerbations (long-term: ≥20 weeks of treatment; short-term: <20 weeks), lung function (≥12 weeks), health-related quality of life, mortality and adverse events. Qualitative comparisons of efficacies between RCTs and observational studies.

Results

212 RCTs and 19 observational studies were included. Compared with combined long-acting beta-adrenoceptor agonists and long-acting muscarinic antagonists (LABA+LAMA), triple therapy (LA

SUBMITTER: Axson EL 

PROVIDER: S-EPMC7526304 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature