Ontology highlight
ABSTRACT:
SUBMITTER: Curtis BJ
PROVIDER: S-EPMC7526323 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Curtis Brian J BJ Kim Lee Joon LJ Wrobel Chester J J CJJ Eagan James M JM Smith Rubin A RA Burch Jessica E JE Le Henry H HH Artyukhin Alexander B AB Nelson Hosea M HM Schroeder Frank C FC
Organic letters 20200821 17
Few nucleoside-derived natural products have been identified from animals, despite the ubiquity of nucleosides in living organisms. Here, we use a combination of synthesis and the emerging electron microscopy technique microcrystal electron diffraction to determine the structures of several <i>N</i><sup>3</sup>-(β-glucopyranosyl)uric acid derivatives in <i>Caenorhabditis elegans</i>. These noncanonical gluconucleosides further integrate an ascaroside moiety, for which we present a shortened synt ...[more]