Immunological and clinicopathological characteristics of C1RL in 2120 glioma patients.

ABSTRACT:

Background

Glioma is a deadly and immunosuppressive brain tumour. Complement C1r subcomponent like (C1RL), a prognostic biomarker in several kinds of tumours, has attracted increasing attention from oncologists. However, the role of C1RL in glioma remains unclear.

Methods

Through analysis of 2120 glioma patients from 5 public datasets, the relationships between C1RL expression and clinicopathological characteristics were evaluated. Furthermore, the C1RL-associated genes were screened, and Gene Ontology (GO) analysis was conducted to investigate biological process enrichment. In addition, tumour purity, leukocyte infiltration and overall survival were evaluated based on C1RL expression.

Results

We found that C1RL expression was upregulated in glioblastoma (GBM), especi

SUBMITTER: Wang J 

PROVIDER: S-EPMC7526369 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature