Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs.

ABSTRACT: More than 90% of autoimmune-associated variants are located in noncoding regions, leading to challenges in deciphering the underlying causal roles of functional variants and genes and biological mechanisms. Therefore, to reduce the gap between traditional genetic findings and mechanistic understanding of disease etiologies and clinical drug development, it is important to translate systematically the regulatory mechanisms underlying noncoding variants. Here, we prioritized functional noncoding SNPs with regulatory gene targets associated with 19 autoimmune diseases by incorporating hundreds of immune cell-specific multiomics data. The prioritized SNPs are associated with transcription factor (TF) binding, histone modification, or chromatin accessibility, indicating their allele-specific re

SUBMITTER: Chen XF 

PROVIDER: S-EPMC7526455 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature