NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.

ABSTRACT: Cellular exposure to ionizing radiation leads to oxidatively generated DNA damage, which has been implicated in neurodegenerative diseases. DNA damage is repaired by the evolutionarily conserved base excision repair (BER) system. Exposure of mice to ionizing radiation affects neurogenesis and neuroinflammation. However, the consequences of deficient DNA repair on adult neurogenesis and neuroinflammation are poorly understood despite their potential relevance for homeostasis. We previously reported that loss of NEIL1, an important DNA glycosylase involved in BER, is associated with deficiencies in spatial memory, olfaction, and protection against ischemic stroke in mice. Here, we show that Neil1^-/- mice display an anxiety-mediated behavior in the open field test, a deficient reco

SUBMITTER: Yang B 

PROVIDER: S-EPMC7526462 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature