Preventing epilepsy after traumatic brain injury: A propensity score analysis.

ABSTRACT:

Background

Due to the potential consequences of post-traumatic epilepsy (PTE) exacerbating secondary injury following traumatic brain injury (TBI), the use of antiepileptic drugs (AEDs) is an accepted option for seizure prophylaxis. However, there is only a paucity of data that can be found regarding outcomes surrounding the use of AEDs. The purpose of this retrospective study is to evaluate whether the prophylactic administration of AEDs significantly decreased the incidence of PTE, when considering the severity of TBI.

Methods

All trauma patients who had been newly diagnosed with TBI from January 1, 2010 to December 31, 2017 were retrospectively analyzed. Statistical comparisons were made using the chi-square test, Mann-Whitney U test, and Cox regression modeling. After ex

SUBMITTER: Liou JH 

PROVIDER: S-EPMC7526576 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature