Tobacco smoking and the risk of Parkinson disease: A 65-year follow-up of 30,000 male British doctors.

ABSTRACT:

Objective

To investigate the causal relevance of current tobacco smoking for the risk of Parkinson disease (PD).

Methods

We compared the risks of death from PD with smoking habits in 30,000 male doctors in the British Doctors cohort study in 1951 and in survivors who had been resurveyed periodically for 5 decades. Cause-specific mortality was monitored for 65 years and included 283 deaths from PD. The relative risks (RRs) of PD (and 95% confidence intervals [CIs]) were estimated using Cox models for smoking habits (smoking status, amount smoked, and years since quitting) at baseline or updated habits at resurvey.

Results

The prevalence of current smoking declined progressively during follow-up from 67% to 8% between 1951 and 1998. The crude rates of PD death were lowe

SUBMITTER: Mappin-Kasirer B 

PROVIDER: S-EPMC7526668 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature