Antiepileptic drug use and mortality among community-dwelling persons with Alzheimer disease.

ABSTRACT:

Objective

To evaluate the risk of death in relation to incident antiepileptic drug (AED) use compared with nonuse in people with Alzheimer disease (AD) through the assessment in terms of duration of use, specific drugs, and main causes of death.

Methods

The MEDALZ (Medication Use and Alzheimer Disease) cohort study includes all Finnish persons who received a clinically verified AD diagnosis (n = 70,718) in 2005-2011. Incident AED users were identified with 1-year washout period. For each incident AED user (n = 5,638), 1 nonuser was matched according to sex, age, and time since AD diagnosis. Analyses were conducted with Cox proportional regression models and inverse probability of treatment weighting (IPTW).

Results

Nearly 50% discontinued AEDs within 6 months. Compare

SUBMITTER: Sarycheva T 

PROVIDER: S-EPMC7526675 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature