Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women.

ABSTRACT:

Context

Lower dehydroepiandrosterone-sulfate (DHEA-S) levels have been inconsistently associated with coronary heart disease (CHD) and mortality. Data are limited for heart failure (HF) and association between DHEA-S change and events.

Objective

Assess associations between low DHEA-S/DHEA-S change and incident HF hospitalization, CHD, and mortality in older adults.

Design

DHEA-S was measured in stored plasma from visits 4 (1996-1998) and 5 (2011-2013) of the Atherosclerosis Risk in Communities study. Follow-up for incident events: 18 years for DHEA-S level; 5.5 years for DHEA-S change.

Setting

General community.

Participants

Individuals without prevalent cardiovascular disease (n = 8143, mean age 63 years).

Main outcome measure

Associations betwee

SUBMITTER: Jia X 

PROVIDER: S-EPMC7526732 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature