Osteopontin RNA aptamer can prevent and reverse pressure overload-induced heart failure.

ABSTRACT:

Aims

Cardiac myocyte hypertrophy, the main compensatory response to chronic stress in the heart often progresses to a state of decompensation that can lead to heart failure. Osteopontin (OPN) is an effector for extracellular signalling that induces myocyte growth and fibrosis. Although increased OPN activity has been observed in stressed myocytes and fibroblasts, the detailed and long term effects of blocking OPN signalling on the heart remain poorly defined. Targeting cardiac OPN protein by an RNA aptamer may be beneficial for tuning down OPN pathologic signalling. We aimed to demonstrate the therapeutic effects of an OPN RNA aptamer on cardiac dysfunction.

Methods and results

In vivo, we show that in a mouse model of pressure overload, treating at the time of surgeries wit

SUBMITTER: Li J 

PROVIDER: S-EPMC7526752 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature