Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.

ABSTRACT:

Introduction

Although next-generation sequencing (NGS) has brought insight into critical mutations or pathways (e.g., DNA damage sensing and repair) involved in the etiology of many cancers and has directed new screening, prevention, and therapeutic approaches for patients and families, it has only recently been used in malignant pleural mesotheliomas (MPMs).

Methods

We analyzed the blood samples from patients with MPM using the NGS platform MSK-IMPACT to explore cancer-predisposing genes. The loss-of-function variants or pathogenic entries were identified, and clinicopathologic information was collected.

Results

Of 84 patients with MPM, 12% (10 of 84) had pathogenic variants. Clinical characteristics were similar between cohorts, although patients with germline patho

SUBMITTER: Guo R 

PROVIDER: S-EPMC7526793 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature