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Genomic Study of bla IMI-Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period.

ABSTRACT: The bla IMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 bla IMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the bla IMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected.

SUBMITTER: Octavia S 

PROVIDER: S-EPMC7526801 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Genomic Study of <i>bla</i><sub>IMI</sub>-Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period.

Octavia Sophie S   Koh Tse Hsien TH   Ng Oon Tek OT   Marimuthu Kalisvar K   Venkatachalam Indumathi I   Lin Raymond T P RTP   Teo Jeanette W P JWP  

Antimicrobial agents and chemotherapy 20200722 8

The <i>bla</i><sub>IMI</sub> gene is rarely detected outside the <i>Enterobacter</i> genus. Genomic characterization of 87 <i>bla</i><sub>IMI</sub>-positive <i>Enterobacter cloacae</i> complex members revealed that the largest phylogenomic clade was made up of <i>E. cloacae</i> subsp. <i>cloacae</i> (71.3%), followed by the newly described species <i>E. bugandensis</i> (13.8%), <i>E. sichuanensis</i> (10.3%), and <i>E. roggenkampii</i> (4.6%). IMI-1 was the predominant carbapenemase variant (86/  ...[more]

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