Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin.

ABSTRACT: Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvumin vitro with limited cytotoxicity (50% effective concentration [EC50] = 120 nM versus 50% cytotoxic concentration [TC50] = 988 nM), and its application disrupted the parasite morphology. This study expands the spectrum of activity of a glycolipopeptide named occidiofungin. Occidiofungin has poor gastrointestinal tract absorption properties, supporting future investigations into its potential activities on other enteric parasites.

SUBMITTER: Ma J 

PROVIDER: S-EPMC7526809 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature