Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis.

ABSTRACT: Candida albicans is a commensal organism that causes life-threatening or life-altering opportunistic infections. Treatment of Candida infections is limited by the paucity of antifungal drug classes. Naturally occurring antimicrobial peptides are promising agents for drug development. CCL28 is a CC chemokine that is abundant in saliva and has in vitro antimicrobial activity. In this study, we examine the in vivo Candida killing capacity of CCL28 in oropharyngeal candidiasis as well as the spectrum and mechanism of anti-Candida activity. In the mouse model of oropharyngeal candidiasis, application of wild-type CCL28 reduces oral fungal burden in severely immunodeficient mice without causing excessive inflammation or altering tissue neutrophil recruitment. C

SUBMITTER: He J 

PROVIDER: S-EPMC7526824 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature