Persistence Dynamics of Antimicrobial-Resistant Neisseria in the Pharynx of Rhesus Macaques.

ABSTRACT: Pharyngeal infections by Neisseria gonorrhoeae are often asymptomatic, making them difficult to treat. However, in vivo animal modeling of human pharyngeal infections by pathogenic Neisseria species is challenging due to numerous host tropism barriers. We have relied on rhesus macaques to investigate pharyngeal persistence of naturally occurring Neisseria species in response to antibiotics. These species include Neisseria mucosa, Neisseria oralis, and a species unique to macaques. Four animals previously treated intramuscularly with the fluoroquinolone enrofloxacin for 2 weeks were monitored for persistence of their preexisting Neisseria populations for a period of 10 weeks. Enrofloxacin exposure did not eliminate preexisting flora from two

SUBMITTER: Thapa E 

PROVIDER: S-EPMC7526842 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature