Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model.

ABSTRACT:

Background

Fibromyalgia patients experience cardiovascular complications in addition to musculoskeletal pain. This study aimed to investigate the cardiac effects of a prolonged shallow water gait in a fibromyalgia-induced young mouse model.

Methods

To produce a fibromyalgia mouse model, wild-type mice were administered an intraperitoneal injection of reserpine once a day for three days, and two primary experiments were performed. First, three types of gait tests were performed before and after the reserpine injections as follows: (i) 5 minutes of free gait outside the water, (ii) 1 minute of free gait in shallow warm water, and (iii) 5 minutes of free gait in shallow warm water. Second, electrocardiogram recordings were taken before and after the three gait tests. The averag

SUBMITTER: Nakata T 

PROVIDER: S-EPMC7526895 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature