Emphysema Index Based on Hyperpolarized ³He or ¹²⁹Xe Diffusion MRI: Performance and Comparison with Quantitative CT and Pulmonary Function Tests.

ABSTRACT: Background Apparent diffusion coefficient (ADC) maps of inhaled hyperpolarized gases have shown promise in the characterization of emphysema in patients with chronic obstructive pulmonary disease (COPD), yet an easily interpreted quantitative metric beyond mean and standard deviation has not been established. Purpose To introduce a quantitative framework with which to characterize emphysema burden based on hyperpolarized helium 3 (³He) and xenon 129 (¹²⁹Xe) ADC maps and compare its diagnostic performance with CT-based emphysema metrics and pulmonary function tests (PFTs). Materials and Methods Twenty-seven patients with mild, moderate, or severe COPD and 13 age-matched healthy control subjects participated in this retrospective study. Participants underwent CT and mul

SUBMITTER: Tafti S 

PROVIDER: S-EPMC7526952 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature