Systematic review of Group B Streptococcal capsular types, sequence types and surface proteins as potential vaccine candidates.

ABSTRACT:

Background

21 million pregnant women worldwide (18%) are estimated to carry Group B Streptococcus (GBS), which is a risk for invasive disease in newborns, pregnant women, and stillbirths. Adults ≥ 60 years or with underlying health conditions are also vulnerable to invasive GBS disease. We undertook systematic reviews on GBS organism characteristics including: capsular polysaccharide (serotype), sequence type (multi-locus sequence types (MLST)), and virulence proteins. We synthesised data by at-risk populations, to inform vaccine development.

Methods

We conducted systematic reviews and meta-analyses to estimate proportions of GBS serotypes for at risk populations: maternal colonisation, invasive disease in pregnant women, stillbirths, infants 0-90 days age, and older adults

SUBMITTER: Bianchi-Jassir F 

PROVIDER: S-EPMC7526974 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature