Confinement in Nanodiscs Anisotropically Modifies Lipid Bilayer Elastic Properties.

ABSTRACT: Lipid nanodiscs are small synthetic lipid bilayer structures that are stabilized in solution by special circumscribing (or scaffolding) proteins or polymers. Because they create native-like environments for transmembrane proteins, lipid nanodiscs have become a powerful tool for structural determination of this class of systems when combined with cryo-electron microscopy or nuclear magnetic resonance. The elastic properties of lipid bilayers determine how the lipid environment responds to membrane protein perturbations, and how the lipid in turn modifies the conformational state of the embedded protein. However, despite the abundant use of nanodiscs in determining membrane protein structure, the elastic material properties of even pure lipid nanodiscs (i.e., without embedded proteins) have

SUBMITTER: Schachter I 

PROVIDER: S-EPMC7526989 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature