Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.

ABSTRACT: Background Klebsiella pneumoniae (hereafter, Kp) is a major public health threat responsible for high levels of multidrug resistant (MDR) human infections. Besides, Kp also causes severe infections in the community, especially in Asia and Africa. Although most Kp infections are caused by endogenous intestinal carriage, little is known about the prevalence and microbiological characteristics of Kp in asymptomatic human carriage, and attached risk factors including environmental sources exposure. Methods Here, 911 pregnant women from communities in Madagascar, Cambodia, and Senegal were screened for gut colonization by Kp. Characteristics of Kp strains (antimicrobial susceptibility, genomic diversity, virulence, and resistance genes) were defined, and associated risk factors were inve

SUBMITTER: Huynh BT 

PROVIDER: S-EPMC7527070 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature