Azithromycin susceptibility of <i>Neisseria gonorrhoeae</i> in the USA in 2017: a genomic analysis of surveillance data.

ABSTRACT:

Background

The number of cases of gonorrhoea in the USA and worldwide caused by Neisseria gonorrhoeae is increasing (555 608 reported US cases in 2017, and 87 million cases worldwide in 2016). Many countries report declining in vitro susceptibility of azithromycin, which is a concern because azithromycin and ceftriaxone are the recommended dual treatment in many countries. We aimed to identify strain types associated with decreased susceptibility to azithromycin.

Methods

We did a genomic analysis of N gonorrhoeae isolates obtained by the US Gonococcal Isolate Surveillance Project. Isolates were whole-genome sequenced based on decreased susceptibility to azithromycin (minimal inhibitory concentration [MIC] ≥2 μg/mL, using agar dilution antibiotic susceptibility

SUBMITTER: Gernert KM 

PROVIDER: S-EPMC7527259 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature