Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise derivatives of bacterial riboflavin metabolites presented by MHC-Ib-related protein 1 (MR1) molecules and are important effector cells for mucosal immunity. Their development can be influenced by the intestinal microbiome. Since the development of type 1 diabetes has been associated with changes in the gut microbiome, this can be hypothesised to lead to alterations in circulating MAIT cells. Accordingly, peripheral blood MAIT cell alterations have been reported previously in patients with type 1 diabetes. However, a comprehensive analysis of the frequency and phenotype of circulating MAIT cells at different stages of type 1 diabetes progression is currently lacking.

Methods

We

SUBMITTER: Gazali AM 

PROVIDER: S-EPMC7527319 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature