Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review.

ABSTRACT:

Purpose

To assess the ability of clinical examination, blood biomarkers, electrophysiology, or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict poor neurological outcome, defined as death, vegetative state, or severe disability (CPC 3-5) at hospital discharge/1 month or later, in comatose adult survivors from cardiac arrest (CA).

Methods

PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews (January 2013-April 2020) were searched. Sensitivity and false-positive rate (FPR) for each predictor were calculated. Due to heterogeneities in recording times, predictor thresholds, and definition of some predictors, meta-analysis was not performed.

Results

Ninety-four studies (30,200 patients) were included. B

SUBMITTER: Sandroni C 

PROVIDER: S-EPMC7527362 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature