Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy.
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ABSTRACT:
SUBMITTER: Daniele G
PROVIDER: S-EPMC7527374 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy.
Daniele Giuseppe G Solis-Herrera Carolina C Dardano Angela A Mari Andrea A Tura Andrea A Giusti Laura L Kurumthodathu Jancy J JJ Campi Beatrice B Saba Alessandro A Bianchi Anna Maria AM Tregnaghi Carla C Egidi Maria Francesca MF Abdul-Ghani Muhammad M DeFronzo Ralph R Del Prato Stefano S
Diabetologia 20200822 11
<h4>Aims/hypothesis</h4>The glucosuria induced by sodium-glucose cotransporter 2 (SGLT2) inhibition stimulates endogenous (hepatic) glucose production (EGP), blunting the decline in HbA<sub>1c</sub>. We hypothesised that, in response to glucosuria, a renal signal is generated and stimulates EGP. To examine the effect of acute administration of SGLT2 inhibitors on EGP, we studied non-diabetic individuals who had undergone renal transplant with and without removal of native kidneys.<h4>Methods</h4 ...[more]
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