Synthesis and evaluation of N-isopropyl-p-[¹¹C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography.

ABSTRACT:

Introduction

Increases in fasting plasma glucose (PG) levels lead to a decrease in 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) uptake in the normal brain, especially in the precuneus, resulting in an Alzheimer's disease (AD)-like uptake pattern. Therefore, patients with higher PG levels, such as those with diabetes, can be erroneously diagnosed with AD when positron emission tomography (PET) imaging is done using [¹⁸F]FDG, due to reduced uptake of [¹⁸F]FDG in the precuneus. To help avoid an erroneous diagnosis of AD due to differences in glucose metabolism, evaluating cerebral blood flow (CBF) in the brain is useful. However, current techniques such as single photon emission computed tomography (SPECT) and [¹⁵O]H₂O PE

SUBMITTER: Toyohara J 

PROVIDER: S-EPMC7527401 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature