Mapping the Interactive Effects of ApoE Gene Polymorphism on Caudate Functional Connectivity in Mild Cognitive Impairment Associated With Parkinson's Disease.

ABSTRACT:

Introduction

Cognitive impairment (CI) is a frequent non-motor symptom of Parkinson's disease (PD). Caudate and Apolipoprotein E (ApoE) are biomarkers linked to CI in PD. There is little known about whether ApoE affects caudate in mild CI of PD (PD-MCI). We investigated the possible interactive effect of ApoE genotypes on caudate functional connectivity (FC) in PD-MCI.

Methods

A total of 95 PD-MCI patients and 99 matched healthy controls underwent extensive neuropsychological assessment and magnetic resonance imaging. The two groups were separated into three subgroups according to their genotyping. Functional data were analyzed with FC analysis.

Results

Decreased FC between the caudate and the bilateral inferior orbit frontal gyrus and bilateral middle occipital gyrus

SUBMITTER: Shang S 

PROVIDER: S-EPMC7527607 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature