Repurposing Pimavanserin, an Anti-Parkinson Drug for Pancreatic Cancer Therapy.

ABSTRACT: Despite major advances in cancer treatment, pancreatic cancer is still incurable and the treatment outcomes are limited. The aggressive and therapy-resistant nature of pancreatic cancer warrants the need for novel treatment options for pancreatic cancer management. Drug repurposing is emerging as an effectual strategy in the treatment of various diseases, including cancer. In the present study, we evaluated the anticancer effects of pimavanserin tartrate (PVT), an antipsychotic drug used for the treatment of Parkinson disease psychosis. PVT significantly suppressed the proliferation and induced apoptosis in various pancreatic cancer cells and gemcitabine-resistant cells with minimal effects on normal pancreatic epithelial cells and lung fibroblasts. Growth-suppressive and apoptotic effects

SUBMITTER: Ramachandran S 

PROVIDER: S-EPMC7527685 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature