Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release

ABSTRACT: Summary A dengue suppression strategy based on release of Aedes aegypti mosquitoes infected with the bacterium Wolbachia pipientis is being trialed in many countries. Wolbachia inhibits replication and transmission of dengue viruses. Questions remain regarding the long-term stability of virus-suppressive effects. We sequenced the Wolbachia genome and analyzed Ae. aegypti mitochondrial DNA markers isolated from mosquitoes sampled 2–8 years after releases in the greater Cairns region, Australia. Few changes were detected when Wolbachia genomes of field mosquitoes were compared with Wolbachia genomes of mosquitoes obtained soon after initial releases. Mitochondrial variants associated with the initial Wolbachia release stock are now the only variants found in release sites, highlighting mater

SUBMITTER: Huang B 

PROVIDER: S-EPMC7527712 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature