A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae.

ABSTRACT: Viruses have developed innovative strategies to exploit the cellular machinery and overcome the antiviral defenses of the host, often using specifically structured RNA elements. Examples are found in the Flavivirus genus (in the family Flaviviridae), where during flaviviral infection, pathogenic subgenomic flaviviral RNAs (sfRNAs) accumulate in the cell. These sfRNAs are formed when a host cell 5' to 3' exoribonuclease degrades the viral genomic RNA but is blocked by an exoribonuclease-resistant RNA structure (xrRNA) located in the viral genome's 3' untranslated region (UTR). Although known to exist in several Flaviviridae genera, the full distribution and diversity of xrRNAs in this family were unknown. Using the recently solved high-resolution structure of an xrRNA f

SUBMITTER: Szucs MJ 

PROVIDER: S-EPMC7527734 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature