Evaluation of oral immunotherapy efficacy and safety by maintenance dose dependency: A multicenter randomized study.

ABSTRACT:

Background

Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the efficacy of treatment with OIT at a low dose has been reported. However, the optimal dose and the evaluation of dose-dependent OIT outcome have not been described.

Methods

A multicenter, parallel, open-labeled, prospective, non-placebo controlled, randomized study enrolled 101 Japanese patients for treatment with OIT. We hypothesized that target dose OIT would induce short-term unresponsiveness (StU) earlier than reduced dose OIT. StU was defined as no response to 6200 mg whole egg, 3400 mg milk, and 2600 mg wheat protein, as evaluated by oral food challenge after 2-week ingestion cessation. To compare the two doses of OIT efficacy, the maximum ingestion doses during the maintenance p

SUBMITTER: Ogura K 

PROVIDER: S-EPMC7527748 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature